This American Life - An NPR podcast that talks about varying topics every week, ranging from the health care system to true urban legends to topics their moms presented. Episodes are about an hour long and are generally presented with some sort of introduction followed by three acts, each a different story relating to the topic then a bit of a closer. I enjoy it, but I can easily see why someone wouldn't.
And that's pretty much all I listen to. Should probably expand it.
Spill.com - Mostly a movie review website but has a podcast section, one I mostly listen to is "Let's do This" which is a random discussion for 2 or more hours, along with a few other podcasts from them on new releases and movie news.
Go Nintendo - They talk about Nintendo and other games, not much to say on it really.
Thrilling Adventure Hour - Recordings of a live comedy show done in the style of old fashioned radio shows. Absolutely hilarious, featuring a bunch of different "series", and a stellar cast, including Paul F Tomkins, John Dimaggio and James Urbaniak. Frequent guest stars include Patton Oswalt and Nathan Fillion.
Talkin' Toons with Rob Paulsen - Classic VOice Actor Rob Paulsen talks about the voice acting biz, and interviews many notable VAs. Great stuff. The John Dimaggio episode will make you die of laughs
We're Alive - A Zombie survival story audio drama. Just discovered this the other night and I've just been eating it up. Great atmosphere, good performances, entertainingly-unconventional zombies and motherfucking Burt. You'll know what I'm talking about.
Comedy Bang! Bang! - Comedy talk show where the host Scott Auckerman interviews a comedian or actor and then brings in a character half way through the interview to disrupt the interview with wild antics. Fun times. Comedy Bang Bang also has a TV version on IFC.
I like the Super Best Friendcast for my gaming stuff, but it just depends on how much of their interests in games you share (like their normally 30-45 minute long segments on the fighting game community). Oh also every episode is almost or over 3 hours long.
I recently started listening to a bad movie review podcast called The Flop House that Kero showed me, and it is hiiiiilarious. All three of the regular guys from the last 50-60 episodes are really quick witted and have a lot of goofs, and it's a real hoot.
Comedy Bang! Bang! is also a great entertaining podcast with a really big library of cool guests to listen to (like Markford said).
From Wiki: Stop Podcasting Yourself is a weekly comedy podcast hosted by Graham Clark and Dave Shumka. Each week the comedy duo invites a guest onto the program for a conversational interview. It is sometimes referred to by its acronym—pronounced "spy"—and its listeners are referred to as "bumpers" after Dave mistakenly referred to the audience that way in episode 1.
Stop Podcasting Yourself started independently on March 2, 2008, being distributed through iTunes and its blog. On March 22, 2010, it was announced that the Vancouver-based podcast would join Maximum Fun.
Legion of Blogcast - for all my Canucks/hockey related stuff, though very little of it is actually hockey centered...
Comic Books Are Burning In Hell is a comics criticism podcast that I like. They're super harsh sometimes but they're very passionate about comic books. Also great for finding new stuff that doesn't get a lot of exposure everywhere else. They also do a movie podcast but I don't listen to that one.
Decompressed is Kieron Gillen's highly irregular comics podcast where he talks in depth about comic craft with creators of certain comics. Lots of really interesting discussion here.
Fatman on Batman is interesting sometimes since Kevin Smith is a pretty great interviewer when he doesn't interrupt and ramble for several minutes about his own bullshit. Great podcast if you want to hear a grown man cry about fucking Batman. Especially the one with Kevin Conroy where Smith makes him do the Batman voice and tell him he's a good director and Kevin Smith just starts weeping.
Inkstuds is one I forget exists a lot. They talk to cartoonists a lot. Just scrolling through the front page I see three that I need to listen to.
Four Eyes and Beard: Scott Mosier (of SModcast, producer and friend of Kevin Smith) and Mitt Mira (of the Nerdist podcast) get together and discuss food, travel, books, and are generally sweet and amusing. Scott Mosier is my favorite person from any SModco Podcast because of his delightful Canadiacity. They are bad at podcasting by themselves though and have had more than a few on-air discussions about technical issues, but thats it.
Fantasy Fiction: Josh and Dom from Continue? on youtube skype to each other and read really dumb hilarious fantasy stories to each other. Lots of boobs n weiners.
Rooster Teeth Podcast: Formerly The Drunk Tank, the makers of Red vs Blue gather round and tell each other a bunch of really funny stories. I don't really watch anything on their youtube channel, but any episode with Joel Heyman on it is great.
Welcome to Night Vale: This has gotten a lot of attention lately, but I'd figure I'd put iut in here anyways because I really enjoy it. Its a radio play of a humble town radio broadcaster coming to you from the mysterious Night Vale and all the crazy shit that happens there. Pretty funny and amazing music, also Cecil has the most beautiful, sultry voice.
Only been doing this podcast thing for the past three or four months, but I now have a few I regularly look out for.
Rage Select Podcast - Pretty much what I started on, thanks to Mega's suggestion. It's regular gaming stuff, with Jeff (something) and Jason Murphy, and it's generally a fun listen. Nothing spectacular, but definitely enjoyable.
Giant Bombcast - I figure most people here who listen to podcasts, and gaming ones in particular, already listen to this one. So all I will say is that Brad Shoemaker sounds exactly like Frent.
Super Joystiq Podcast - More gaming stuff, this time from Joystiq. It's lead by Ludwig Kietzmann, who I like to hear from, and it's usually pretty on point. A couple of the podcast regulars get on my nerves (Anthony John Agnello and Susan Arendt), but it's still generally an entertaining listen.
IGN AU Pubcast - When there's nothing else, I finally end up turning to IGN. The only IGN podcast that I honestly really enjoy is the Australian one. Everyone on it is funny and seems to be... I guess a lot less annoying than those on their main American or PlayStation counterparts? Or not annoying at all. Either way, I like it.
The Jalen Rose Report - This is an NBA one. Former player Jalen Rose and Grantland editor David Jacoby sit down and talk about the state of basketball, the league, its players, music, food, cities, whatever strikes their fancy. Unlike other NBA (or sports) related podcasts I hear, it's not necessarily relating to the games of that night, but to the state of the game of basketball as a whole (and many other things), so it's easy to go back and listen to older episodes and still get something out of them. The two of them also like to have a lot of fun (and give the people what they want).
The Starters - This is NBAtv's official podcast and is a little more topical and by the numbers from a night to night perspective. I don't tend to listen to it as often if I have other options, but it's definitely a fallback.
A Couple of Cold Ones - This was a Spill.com movie review podcast and I only just started listening to it as it was being shut down. Hollywood.com decided to close down Spill.com and all the podcasts went with it. Now it's a matter of waiting for Korey Coleman to get his new podcast (in the link) up and running for good. Haven't really found any other movie podcasts I like as much as this one.
I got around to listening to that this week, a little too developer sided for me. Can't really relate so far. Toilet stuff is pretty funny though.
Really? It seems like one of the least business oriented podcasts I've listened to. Matter of fact, I think that's even part of their mission statement. Maybe it was just this week's podcast? 'Cause they have a couple of developer people on this week and are talking about things they rarely talk about.